Human Health Impact Study

  • “Quaternary ammonium compounds (Quats) are a large class of … chemicals that are used in a variety of consumer and industrial products for their antimicrobial properties.”
  • “[Quats] are poorly absorbed via the oral and dermal exposure routes, are not systemically distributed....”
  • “European Chemicals Agency (ECHA) concluded that oral and dermal absorption … is limited, and does not exceed 10%.”
  • “..Collectively, available guideline studies indicate that [Quats] are not specific or primary reproductive or developmental toxicants, which is consistent with the conclusions of the Environmental Protection Agency (EPA) (2006a,b) and ECHA (2015a,b).”
  • “EPA’s Cancer Assessment Review Committee classified [Quats] as 'not likely to be carcinogenic to humans' and 'Group E – evidence of non-carcinogenicity for humans,' respectively (EPA 2018).”
  • “[Biocidal Quats] are not dermal sensitizers, are not specific developmental or reproductive toxicants, are not carcinogenic or genotoxic, and do not cause systemic toxicity.”
  • “When conducting their risk assessments for [biocidal quats], EPA (2006a,b) determined that a FQPA [Food Quality Protection Act of 1996] Safety Factor was not needed to protect sensitive human subpopulations (i.e., infants and children) from exposure ….”
  • “The EPA’s Hazard and Science Policy Council (HASPOC) reviewed the toxicology database [biocidal quats] and waived the requirements for immunotoxicity and acute and subchronic neurotoxicity testing based on the weight of evidence that strongly suggests that these studies would not result in a lower point of departure for use in risk assessment (EPA 2016a,b).”

Luz, A et al. Human health hazard assessment of quaternary ammonium compounds: Didecyl dimethyl ammonium chloride and alkyl (C12–C16) dimethyl benzyl ammonium chloride Regulatory Toxicology and Pharmacology, Oct, 2020.